USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.

@article{Sun2010USP11NR,
  title={USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.},
  author={Wenjing Sun and Xiaojie Tan and Yi Shi and Gufeng Xu and Renfang Mao and Xue Gu and Yihui Fan and Yonghao Yu and Susan M Burlingame and Hong Juan Zhang and Surya P. Rednam and Xiongbin Lu and Ting Zhang and Songbin Fu and Guangwen Cao and Jun Qin and Jianhua Yang},
  journal={Cellular signalling},
  year={2010},
  volume={22 3},
  pages={386-94}
}
IkappaBalpha serves as a central anchoring molecule in the sequestration of NF-kappaB transcription factor in the cytoplasm. Ubiquitination-mediated IkappaBalpha degradation immediately precedes and is required for NF-kappaB nuclear translocation and activation. However, the precise mechanism for the deubiquitination of IkappaBalpha is still not fully understood. Using a proteomic approach, we have identified Ubiquitin Specific Peptidase 11 (USP11) as an IkappaBalpha associated deubiquitinase… CONTINUE READING
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