USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

@inproceedings{Guervilly2011USP1DM,
  title={USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation},
  author={Jean-Hugues Guervilly and Emilie Renaud and Minoru Takata and Filippo Rosselli},
  booktitle={Human molecular genetics},
  year={2011}
}
The maintenance of genetic stability depends on the fine-tuned initiation and termination of pathways involved in cell cycle checkpoints and DNA repair. Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element controlling both checkpoints and DNA repair. We show that the ubiquitin-specific peptidase 1 (USP1) deubiquitinase participates in the maintenance of both total and phosphorylated levels of CHK1 in response to genotoxic stress. We establish that… CONTINUE READING
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