USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

@article{Guervilly2011USP1DM,
  title={USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation},
  author={J H Guervilly and Emilie Renaud and Minoru Takata and Filippo Rosselli},
  journal={Human Molecular Genetics},
  year={2011},
  volume={20},
  pages={2171 - 2181}
}
  • J H Guervilly, Emilie Renaud, +1 author Filippo Rosselli
  • Published 2011
  • Biology, Medicine
  • Human Molecular Genetics
  • The maintenance of genetic stability depends on the fine-tuned initiation and termination of pathways involved in cell cycle checkpoints and DNA repair. Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element controlling both checkpoints and DNA repair. We show that the ubiquitin-specific peptidase 1 (USP1) deubiquitinase participates in the maintenance of both total and phosphorylated levels of CHK1 in response to genotoxic stress. We establish that… CONTINUE READING

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