USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis.

  title={USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis.},
  author={Debashree Ray and James S. Pankow and Saonli Basu},
  journal={Genetic epidemiology},
  volume={40 1},
Genome-wide association studies (GWASs) for complex diseases often collect data on multiple correlated endo-phenotypes. Multivariate analysis of these correlated phenotypes can improve the power to detect genetic variants. Multivariate analysis of variance (MANOVA) can perform such association analysis at a GWAS level, but the behavior of MANOVA under different trait models has not been carefully investigated. In this paper, we show that MANOVA is generally very powerful for detecting… CONTINUE READING

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