US intergroup anal carcinoma trial: tumor diameter predicts for colostomy.

@article{Ajani2009USIA,
  title={US intergroup anal carcinoma trial: tumor diameter predicts for colostomy.},
  author={Jaffer A. Ajani and Kathryn A Winter and Leonard L. Gunderson and John Erling Pedersen and Al Bowen Benson and Charles R. Thomas and Robert J. Mayer and Michael G. Haddock and Tyvin A. Rich and Christopher G Willett},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 7},
  pages={1116-21}
}
PURPOSE The US Gastrointestinal Intergroup Radiation Therapy Oncology Group 98-11 anal carcinoma trial showed that cisplatin-based concurrent chemoradiotherapy resulted in a significantly higher rate of colostomy compared with mitomycin-based therapy. Established prognostic variables for patients with anal carcinoma include tumor diameter, clinical nodal status, and sex, but pretreatment variables that would predict the likelihood of colostomy are unknown. METHODS A secondary analysis was… CONTINUE READING

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