UPR-inducible miRNAs contribute to stressful situations.


The endoplasmic reticulum (ER) senses both extracellular and intracellular stresses that can disrupt its ability to facilitate the maturation of proteins destined for secretory pathways. The accumulation of misfolded proteins within the ER triggers an adaptive signaling pathway coined the unfolded protein response (UPR). UPR activation contributes to cell adaptation by reducing the rate of protein translation while increasing the synthesis of chaperones. Although we have gained considerable insight into the mechanisms that regulate gene expression and certain aspects of protein translation, the contribution of miRNAs to UPR-dependent activities has only recently been investigated. Here we highlight recent insights into the contribution of miRNAs to UPR-dependent cellular adaptive responses.

DOI: 10.1016/j.tibs.2013.06.012
Citations per Year

172 Citations

Semantic Scholar estimates that this publication has 172 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Chitnis2013UPRinducibleMC, title={UPR-inducible miRNAs contribute to stressful situations.}, author={Nilesh S Chitnis and Dariusz Pytel and John Alan Diehl}, journal={Trends in biochemical sciences}, year={2013}, volume={38 9}, pages={447-52} }