UPF3 suppresses aberrant spliced mRNA in Arabidopsis.

  title={UPF3 suppresses aberrant spliced mRNA in Arabidopsis.},
  author={Koichi Hori and Yuichiro Watanabe},
  journal={The Plant journal : for cell and molecular biology},
  volume={43 4},
It has been reported that eukaryotic organisms have a nonsense-mediated mRNA decay (NMD) system to exclude aberrant mRNAs that produce truncated proteins. NMD is an RNA surveillance pathway that degrades mRNAs possessing premature translation termination codons (PTCs), thus avoiding production of possibly toxic truncated proteins. Three interacting proteins, UPF1, UPF2 and UPF3, are required for NMD in mammals and yeasts, and their amino acid sequences are well conserved among most eukaryotes… CONTINUE READING
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