UPDATE ON RETINOBLASTOMA

@article{Abramson2004UPDATEOR,
  title={UPDATE ON RETINOBLASTOMA},
  author={David H. Abramson and Amy C. Schefler},
  journal={Retina},
  year={2004},
  volume={24},
  pages={828-848}
}
After completion of this article, the reader will be able to 1) state the therapeutic interventions that are currently used to treat intraocular retinoblastoma, and to outline the mechanism of action, indications, contra-indications, and current success rates for each form of treatment; 2) outline the current understanding of the genetics of retinoblastoma including the location and size of the retinoblastoma gene, the role of the retinoblastoma protein in the cell cycle, the basic idea behind… Expand
Frontiers in the management of retinoblastoma.
TLDR
The management of retinoblastoma has become a prototype for other ophthalmic diseases and systemic cancers in which genetic information and molecular targets are being used to design more elegant treatment strategies. Expand
Update on the Treatment of Retinoblastoma.
TLDR
The clinical presentation, diagnosis, and management of Retinoblastoma is reviewed, with a focus on the newest treatment approaches. Expand
Retinoblastoma: Clinician and patient perspectives
TLDR
The epidemiology, signs and symptoms and treatment of retinoblastoma, the most common malignant tumour of the eye in children, and the support work carried out with individuals and families affected by retinOBlastoma by UK charity the Childhood Eye Cancer Trust are given. Expand
Historical and modern approaches to chemotherapy for retinoblastoma
TLDR
The current strategy for the utilization of chemotherapeutic agents for retinoblastoma, including intravenous delivery, subconjunctival injections and intra-arterial administration is discussed, and the current uses of chemotherapy for metastatic disease are reviewed. Expand
Current Management in Retinoblastoma
TLDR
The primary goal of management of retinoblastoma is life salvage, and secondary and tertiary goals include globe salvage and vision salvage, respectively, and thus improvement of the quality of life of the child. Expand
Retinoblastoma: Genetics and Pathology
TLDR
There is some evidence of increased incidence of nonhereditary retinoblastoma in lower socioeconomic groups, and the discovery of HPV DNA sequences in some retinOBlastoma tumors has led to the hypothesis that it might be one of the causes of this association. Expand
A Review on Local Chemotherapy for Treatment of Retinoblastoma
TLDR
In this review, chemotherapeutic drug delivery as peribulbar, intraophthalmic artery and/or intravitreal injections and finally gene therapy and use of vectors for local delivery of drugs and genes are presented. Expand
Complete Clinical Spectrum of Retinoblastoma
TLDR
The purpose of this manuscript is to review and emphasize atypical clinical presentations simulating orbital cellulitis, uveitis and endophthalmitis among others that encompass the clinical spectrum of retinoblastoma and comment on current management recommendations. Expand
Does pre-enucleation chemotherapy lead to increased risk of metastasis in advanced retinoblastoma?
  • Batriti S Wallang, S. Rath
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2011
TLDR
Despite the deaths described in the article in the pre-enucleation chemotherapy group, a large majority (93%) of children did not develop metastasis and the rationale behind chemoreduction is to downstage the tumor. Expand
Consequences of Delayed Diagnosis in Treatment of Retinoblastoma
TLDR
Early diagnosis of retinoblastoma can be the primary factor in managing the patients as the delay in diagnosis accounts for highly advanced disease and poor prognosis. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 144 REFERENCES
The surgical management of retinoblastoma.
TLDR
Surgical techniques, indications and complications of retinoblastoma are discussed: exenteration, enucleation, diathermy, Xenon arc photocoagulation, cryopexy and the use of local cobalt 60 plaques. Expand
Retinoblastoma. A study of 139 cases.
TLDR
All the patients with retinoblastoma seen at this Unit since I960 are reviewed and a total of I69 cases was seen and treated; as most of the latter had been referred from foreign countries for treatment and had subsequently returned home, they have been excluded from the analysis of results. Expand
Treatment results of retinoblastoma at indiana university hospitals
TLDR
A review of all cases of retinoblastoma seen at Indiana University Hospitals over the past 25 years to determine the results of treatment and causes of failure concludes that visual acuity has been preserved in all 16 patients with unilateral disease and a range of 20/50 to 20/20 in 12 of the16 patients with bilateral disease. Expand
Chemoreduction in the initial management of intraocular retinoblastoma.
TLDR
Tumor shrinkage with chemoreduction may allow treatment with less invasive measures, such as cryotherapy, laser photocoagulation, thermotherapy, or plaque radiotherapy, thereby avoiding enucleation and external beam radiotherapy. Expand
Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma.
TLDR
Although most of the treated group V eyes could be salvaged with chemotherapy plus radiotherapy, the resultant visual acuity was often poor, and of the 12 surviving children, 5 have aVisual acuity better than l/60 in at least 1 eye. Expand
A prospective study on the treatment of retinoblastoma in 72 patients
TLDR
Patients with retinoblastoma were studied for a period of 6 years and the overall survival rates were 79% for unilateral disease and 72% for bilateral disease and vision was regained in 14 of 21 conserved eyes. Expand
Chemotherapy for retinoblastoma.
TLDR
Focal therapy, consisting of photocoagulation, thermotherapy, cryotherapy, or brachytherapy, is necessary to consolidate chemotherapy response. Expand
Trilateral retinoblastoma--incidence and outcome: a decade of experience.
TLDR
Trilateral retinoblastoma is a major and under-appreciated cause of mortality in the first 5 years after the diagnosis of bilateral retinOBlastoma, and a more aggressive approach toward screening a defined population of childhood retin Oblastoma survivors may be warranted. Expand
The genetics of retinoblastoma and current diagnostic testing.
TLDR
The genetics of retinoblastoma and the most recent molecular detection methods are reviewed to help ensure that more comprehensive treatment plans and accurate genetic counseling for affected individuals and their families are provided. Expand
Chemoreduction and local ophthalmic therapy for intraocular retinoblastoma.
TLDR
In retinoblastoma patients with Reese-Ellsworth eye groups 1, 2, or 3, systemic chemotherapy used with local ophthalmic therapies can eliminate the need for enucleation or EBRT without significant systemic toxicity. Expand
...
1
2
3
4
5
...