UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Abstract

Energy deregulation and abnormalities of tumor cell metabolism are critical issues in understanding cancer. Hereditary leiomyomatosis renal cell carcinoma (HLRCC) is an aggressive form of RCC characterized by germline mutation of the Krebs cycle enzyme fumarate hydratase (FH), and one known to be highly metastatic and unusually lethal. There is considerable… (More)
DOI: 10.1016/j.cancergencyto.2009.08.018

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Cite this paper

@article{Yang2010UOK2C, title={UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.}, author={Youfeng Yang and Vladimir A. Valera and Hesed M. Padilla-Nash and Carole Sourbier and Cathy D. Vocke and Manish A. Vira and Mones S. Abu-Asab and Gennady Bratslavsky and Maria G Tsokos and Mar{\'i}a Merino and Peter A. Pinto and Ramaprasad Srinivasan and Thomas Ried and Leonard M. Neckers and W. Marston Linehan}, journal={Cancer genetics and cytogenetics}, year={2010}, volume={196 1}, pages={45-55} }