UNIDENTIFIED CURVED BACILLI ON GASTRIC EPITHELIUM IN ACTIVE CHRONIC GASTRITIS

@article{Warren1983UNIDENTIFIEDCB,
  title={UNIDENTIFIED CURVED BACILLI ON GASTRIC EPITHELIUM IN ACTIVE CHRONIC GASTRITIS},
  author={John R. Warren and Barry J. Marshall},
  journal={The Lancet},
  year={1983},
  volume={321},
  pages={1273-1275}
}
View on Elsevier
med.mcgill.ca
3,037 Citations
Highly Influential Citations
39
Background Citations
603
Methods Citations
31
Results Citations
10

Figures from this paper

3,037 Citations

Campylobacter pylori in gastroduodenal disease.
  • R. Baqai
  • Medicine
    JPMA. The Journal of the Pakistan Medical Association
  • 1988
TLDR
Microbiological, serological and therapeutic data strongly implicate C. Pylori as the pathogen of chronic active gastritis but the nature of association between CLO and histologically abnormal gastric mucosa needs to be defined.
Campylobacter-like organisms and surface epithelium abnormalities in active, chronic gastritis in humans: an ultrastructural study.
TLDR
At the ultrastructural level, the presence of cell necrosis and autolytic intracytoplasmic vacuoles combined with damaged bacteria may suggest a relationship between GCLO surface colonization and erosive epithelial abnormality.
Bacteria of the gastric antrum and their relation to chronic gastritis
TLDR
There is an increased frequency of histological gastritis when Campylobacter pylori is present in the samples, and a causative role of the bacteria could not be demonstrated in this study, and bacterial penetration into the epithelium was not observed.
Campylobacter pyloridis, gastritis, and peptic ulceration.
TLDR
Histological examination of gastric biopsy tissue has shown that C pyloridis is strongly associated with active chronic gastritis, and is not found on normal mucosa except when a biopsy specimen from elsewhere in the stomach shows active chronic Gastritis.
Gastric pathology associated with Helicobacter pylori.
  • J. Warren
  • Medicine
    Gastroenterology clinics of North America
  • 2000
Bacteria in ulcer pathogenesis.
  • N. Yeomans
  • Medicine
    Bailliere's clinical gastroenterology
  • 1988
Campylobacter-like organisms and gastritis: histopathology, bile reflux, and gastric fluid composition.
TLDR
The results confirm that CLO are associated with gastritis, most notably superficial gastritis in the body and atrophic gast arthritis in the antrum, but their aetiological significance remains to be proved.
Acute gastritis associated with spiral organisms from cats
TLDR
Evidence is provided that another bacterium, aGastrospirillum, may cause gastritis in man and may be transmitted from animal to man.
New spiral bacterium in gastric mucosa.
TLDR
A new spiral bacterium, distinct from Campylobacter pylori, was found in the gastric mucosa of six patients with gastrointestinal symptoms, and it is not possible to say from this small series whether these organisms cause chronic active gastritis.
Helicobacter Pylori and Reflux Disease
TLDR
H. pylori colonization is virtually always accompanied by chronic active gastritis, which increases the individual’s risk for the development of several gastroduodenal diseases, such as gastric and duodental ulceration, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and distal gastric cancer, making it a pathogen of great significance.
...
...

References

SHOWING 1-10 OF 24 REFERENCES
Endoscopic, histological and ultrastructural correlations in chronic gastritis.
TLDR
Endoscopic diagnosis should be restricted to presence or absence of gastritis, leaving the specific typing to histological assessment of the gastric biopsies, although it has elucidated the various cellular changes which characterize chronic gastritis.
Influence of gastric pH on gastric and jejunal flora.
TLDR
Those with intact stomachs and those in whom direct continuity between the stomach and jejunum had been established by operation are investigated, providing a wide range of gastric pH.
Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons.
Electron microscopy of Campylobacter jejuni.
  • P. Pead
  • Medicine, Biology
    Journal of medical microbiology
  • 1979
TLDR
Stools from 56 patients with gastroenteritis were cultured for Campylobacter jejuni and the five strains isolated were examined by electron microscopy and most displayed appearances similar to those of V. fetus.
Electron Microscope Observations on the Fine Structure of Parietal Cells
TLDR
These experiments show that under histamine stimulation all these cells undergo a great increase in the cell membrane area, providing additional circumstantial evidence that parietal cells play a role in the secretion of hydrochloric acid.
THE FINE STRUCTURE AND MODE OF ATTACHMENT OF THE SHEATHED FLAGELLUM OF VIBRIO METCHNIKOVII
TLDR
The sheathed flagellum of Vibrio metchnikovii was chosen for a study of the attachment of the flagella to the bacterial cell and electron micrographs of autolysed bacteria negatively stained with potassium phosphotungstate show that the core ends in a basal disc just inside the plasma membrane.
Platelet Consumption by Arterial Prostheses: The Effects of Endothelialization and Pharmacologic Inhibition of Platelet Function
TLDR
Placement of impervious knitted Dacron velour aortic grafts in baboons reproduced platelet consumption that progressively normalized over six weeks postoperatively, implying that endothelialization of the graft surface was also occurring post operatively in patients.
HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION
Modulation of sympathetic vascular tone by prostaglandins in corticosterone-induced hypertension in rats.
TLDR
It is suggested that corticosterone induces a supersensitivity to noradrenaline by inhibiting the biosynthesis of prostaglandins, and changes in the sensitivity of the vascular smooth muscle may play a role in the development of glucocorticoid hypertension.
EFFECT OF ACTH ADMINISTRATION ON THE HAEMODYNAMIC RESPONSE TO ARGININE‐VASOPRESSIN IN SHEEP
TLDR
Blood pressure, heart rate and cardiac output were studied in intact conscious sheep during AVP infusion to determine whether pressor responsiveness to AVP was altered in ACTH‐induced hypertension.
...
...