UNEXPECTEDLY HIGH ENTRAPMENT EFFI- CIENCIES IN NANOMETER SCALE LIPOSOMES WITH HYDRODYNAMIC FOCUSING USING CONTINUOUS-FLOW MICROFLUIDICS

@inproceedings{Jahn2008UNEXPECTEDLYHE,
  title={UNEXPECTEDLY HIGH ENTRAPMENT EFFI- CIENCIES IN NANOMETER SCALE LIPOSOMES WITH HYDRODYNAMIC FOCUSING USING CONTINUOUS-FLOW MICROFLUIDICS},
  author={Andreas Jahn and Joseph E Reiner and Wyatt N. Vreeland and Don L. DeVoe and Laurie E. Locascio and Mart{\'i}n Gait{\'a}n},
  year={2008}
}
A method is presented for achieving high entrapment efficiencies of a hydrophilic drug simulant, sulforhodamine B (SRB), in nanometer-scale liposomes using a continuous-flow microfluidic system. Liposome size and size dispersion are determined using tandem Asymmetric Flow Field Flow Fractionation (AF) and Multi-Angle Laser Light Scattering (MALLS). The average number of encapsulated SRB molecules in a single liposome is measured with Fluorescence Correlation Spectroscopy (FCS) and Fluorescence… CONTINUE READING

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  • A. Jahn, W. N. Vreeland, D. L. DeVoe, L. E. Locascio
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  • 2007
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