UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation.

Abstract

The UCS family of proteins regulates cellular functions through their interactions with myosin. Here we show that one member of this family, UNC45A, is also a novel centrosomal protein. UNC45A is required for cellular proliferation of cancer cell in vitro and for tumor growth in vivo through its ability to bind and regulate ChK1 nuclear-cytoplasmic… (More)
DOI: 10.1016/j.canlet.2014.11.009

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