UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.

@article{Miller2008UNC98AU,
  title={UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.},
  author={Rachel K. Miller and Hiroshi Qadota and Kristina B. Mercer and Kim M. Gernert and Guy M. Benian},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 4},
  pages={
          1529-39
        }
}
Mutations in unc-96 or -98 cause reduced motility and a characteristic defect in muscle structure: by polarized light microscopy birefringent needles are found at the ends of muscle cells. Anti-paramyosin stains the needles in unc-96 and -98 mutant muscle. However there is no difference in the overall level of paramyosin in wild-type, unc-96, and -98 animals. Anti-UNC-98 and anti-paramyosin colocalize in the paramyosin accumulations of missense alleles of unc-15 (encodes paramyosin). Anti-UNC… CONTINUE READING