UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons

@article{Teichmann2011UNC6AU,
  title={UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons},
  author={Hannah M Teichmann and Kang Shen},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={165-172}
}
Axons navigating through the developing nervous system are instructed by external attractive and repulsive cues. Emerging evidence suggests the same cues control dendrite development, but it is not understood how they differentially instruct axons and dendrites. We studied a C. elegans motor neuron whose axon and dendrite adopt different trajectories and lengths. We found that the guidance cue UNC-6 (Netrin) is required for both axon and dendrite development. Its repulsive receptor UNC-5… CONTINUE READING

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