UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.

@article{Killeen2002UNC5FR,
  title={UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.},
  author={Marie Killeen and Jeifei Tong and Aldis Krizus and Robert M. Steven and Ian Scott and Tony J. Pawson and Joseph G Culotti},
  journal={Developmental biology},
  year={2002},
  volume={251 2},
  pages={348-66}
}
Members of the UNC-5 protein family are transmembrane receptors for UNC-6/netrin guidance cues. To analyze the functional roles of different UNC-5 domains, we sequenced mutations in seven severe and three weak alleles of unc-5 in Caenorhabditis elegans. Four severe alleles contain nonsense mutations. Two weak alleles are truncations of the cytodomain, but one is a missense mutation in an extracellular immunoglobulin domain. To survey the function of different regions of UNC-5, wild-type and… CONTINUE READING

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