UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex

Abstract

Many cells in a developing embryo, including neurons and their axons and growth cones, must integrate multiple guidance cues to undergo directed growth and migration. The UNC-6/netrin, SLT-1/slit, and VAB-2/Ephrin guidance cues, and their receptors, UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph, are known to be major regulators of cellular growth and migration. One… (More)
DOI: 10.1371/journal.pgen.1002863

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@inproceedings{Bernadskaya2012UNC40DCCSA, title={UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex}, author={Yelena Y. Bernadskaya and Andre Wallace and Jillian Nguyen and William Mohler and Martha C. Soto}, booktitle={PLoS genetics}, year={2012} }