UNC-1 Regulates Gap Junctions Important to Locomotion in C. elegans

@article{Chen2007UNC1RG,
  title={UNC-1 Regulates Gap Junctions Important to Locomotion in C. elegans},
  author={Bojun Chen and Qiang Liu and Qian Ge and Jia Hua Xie and Zhao-Wen Wang},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1334-1339}
}
In C. elegans, loss-of-function (lf) mutations of the stomatin-like protein (SLP) UNC-1 and the innexin UNC-9 inhibit locomotion [1, 2] and modulate sensitivity to volatile anesthetics [3, 4]. It was unknown why unc-1(lf) and unc-9(lf) mutants have similar phenotypes. We tested the hypothesis that UNC-1 is a regulator of gap junctions formed by UNC-9. Analyses of junctional currents between body-wall muscle cells showed that electrical coupling was inhibited to a similar degree in unc-1(lf… CONTINUE READING
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