UMMS-4 enhanced sensitivity of chemotherapeutic agents to ABCB1-overexpressing cells via inhibiting function of ABCB1 transporter.

@article{Qiao2014UMMS4ES,
  title={UMMS-4 enhanced sensitivity of chemotherapeutic agents to ABCB1-overexpressing cells via inhibiting function of ABCB1 transporter.},
  author={Dongjuan Qiao and Shangjun Tang and Sana Aslam and Matloob Ahmad and Kenneth Kin Wah To and Fang Wang and Zhencong Huang and Jiye Cai and Liwu Fu},
  journal={American journal of cancer research},
  year={2014},
  volume={4 2},
  pages={148-60}
}
Multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters through efflux of antineoplastic agents from cancer cells is a major obstacle to successful cancer chemotherapy. The inhibition of these ABC transporters is thus a logical approach to circumvent MDR. There has been intensive research effort to design and develop novel inhibitors for the ABC transporters to achieve this goal. In the present study, we evaluated the ability of UMMS-4 to modulate P-glycoprotein (P-gp… CONTINUE READING

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