UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions.

Abstract

UM4D4 (CDw60), the surface molecule of a novel antigen-independent T-cell activation pathway, was found to be highly expressed on lesional psoriatic T cells. To examine whether UM4D4 represents a T-cell activation pathway for psoriatic T cells, a T-cell line was initiated from an acute skin lesion and cloned by limiting dilution. Clonality was verified by… (More)

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Cite this paper

@article{Baadsgaard1990UM4D4T, title={UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions.}, author={Ole Baadsgaard and Philip L Tong and James T. Elder and Erik Ren{\'e} Hansen and Vincent C. Ho and Craig Hammerberg and G Lange-Vejlsgaard and David A Fox and Gary J. Fisher and Lawrence S. Chan}, journal={The Journal of investigative dermatology}, year={1990}, volume={95 3}, pages={275-82} }