Corpus ID: 9091384

UK-315716/UK-240455. Pfizer.

  title={UK-315716/UK-240455. Pfizer.},
  author={A. Capelli and F. Micheli},
  journal={Current opinion in investigational drugs},
  volume={2 12},
Pfizer is developing the atropoisomeric quinoxalinediones, UK-315716 and UK-240255, from a series of NMDA/glycine antagonists for the potential treatment of stroke. Both are compounds are undergoing clinical trials. UK-315716 has improved aqueous solubility and in vivo efficacy over UK-240455, and a lower projected clinical dose of 200 mg compared to 500 mg with UK-240455. 
1 Citations
Assessing atropisomer axial chirality in drug discovery and development.
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