UHRF1 promotes proliferation of gastric cancer via mediating tumor suppressor gene hypermethylation.

Abstract

Epigenetic changes play significant roles in cancer development. UHRF1, an epigenetic regulator, has been shown to be overexpressed and to coordinate tumor suppressor gene (TSG) silencing in several cancers. In a previous study, we found that UHRF1 promoted gastric cancer (GC) invasion and metastasis. However, the role and underlying mechanism of UHRF1 in… (More)
DOI: 10.1080/15384047.2015.1056411

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