UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

@article{Mudbhary2014UHRF1OD,
  title={UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.},
  author={Raksha Mudbhary and Yujin Hoshida and Yelena Chernyavskaya and Vinitha Jacob and Augusto Villanueva and Maria Isabel Fiel and Xintong Chen and Kensuke Kojima and Swan N. Thung and Roderick Terry Bronson and Anja Lachenmayer and K. L. Revill and Clara Alsinet and Ravi Sachidanandam and Anal Desai and Sucharita Senbanerjee and Chinweike Ukomadu and Josep M Llovet and Kirsten C Sadler},
  journal={Cancer cell},
  year={2014},
  volume={25 2},
  pages={196-209}
}
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of DNA methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, cultured cells, and human tumors to demonstrate that UHRF1 is an oncogene. UHRF1 overexpression in zebrafish hepatocytes destabilizes and delocalizes Dnmt1 and causes DNA hypomethylation and Tp53-mediated senescence. Hepatocellular carcinoma (HCC) emerges when senescence is bypassed. tp53 mutation both alleviates… CONTINUE READING
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