UHRF1 discriminates against binding to fully-methylated CpG-Sites by steric repulsion.

Abstract

Cytosine methylation of CpG dinucleotide sequence is an epigenetic mark on the DNA that regulates gene expression, chromatin structure, and genome stability. Although the enzyme that catalyzes the methylation reaction after replication is Dnmt1, it was found that the protein UHRF1 is essential for maintaining DNA methylation. UHRF1 exhibits preferential… (More)
DOI: 10.1016/j.bpc.2012.10.002

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