UHRF1 Promotes Cell Growth and Metastasis Through Repression of p16ink4a in Colorectal Cancer

@article{Wang2011UHRF1PC,
  title={UHRF1 Promotes Cell Growth and Metastasis Through Repression of p16ink4a in Colorectal Cancer},
  author={Feng Wang and MS Yong-ZhiYang and Chen-Zhang Shi and Peng Zhang and Mary Pat Moyer and Hui-Zhen Zhang and Yang Zou and Huanlong Qin},
  journal={Annals of Surgical Oncology},
  year={2011},
  volume={19},
  pages={2753-2762}
}
To investigate whether ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) expression is upregulated in colorectal cancer (CRC), whether UHRF1 promotes CRC cell growth and migration and the underlying molecular mechanism. UHRF1 protein expression was determined in 144 pairs of primary CRC and their corresponding adjacent nontumor tissues by immunohistochemistry with tissue microarrays. UHRF1 mRNA expression was assessed in 20 pairs of the above tissues and four colon cancer… CONTINUE READING
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