UGT2B7_−161C>T Polymorphism Is Associated With Lamotrigine Concentration-to-Dose Ratio in a Multivariate Study

@article{BlancaSnchez2010UGT2B7\_161CTPI,
  title={UGT2B7\_−161C>T Polymorphism Is Associated With Lamotrigine Concentration-to-Dose Ratio in a Multivariate Study},
  author={Mar{\'i}a Blanca S{\'a}nchez and Jos{\'e} Luis Herranz and Carlos Leno and Rosa Arteaga and Agust{\'i}n Oterino and Elsa Mar{\'i}a Valdiz{\'a}n and Josep Mar{\'i}a Nicol{\'a}s and Javier Ad{\'i}n and Mehrdad Shushtarian and Juan A. Armijo},
  journal={Therapeutic Drug Monitoring},
  year={2010},
  volume={32},
  pages={177-184}
}
Lamotrigine (LTG) is metabolized by UGT1A4 but UGT2B7 also contributes to its glucuronidation. The aim of this study was to determine whether UGT2B7_− 161C>T and UGT2B7_372A>G polymorphisms contribute to the intersubject variability in LTG concentration-to-dose ratio (LTG-CDR) in epileptic patients. Fifty-three white epileptic patients attending the Neuropediatric and Neurology Services at the Marqués de Valdecilla University Hospital, in whom LTG serum concentration was to be measured for… 

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The present study identified genetic factors associated with CBZ Therapy optimization and provided useful information for individualized CBZ therapy in epileptic patients.
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