UGT2B7_−161C>T Polymorphism Is Associated With Lamotrigine Concentration-to-Dose Ratio in a Multivariate Study

@article{Snchez2010UGT2B7_161CTPI,
  title={UGT2B7_−161C>T Polymorphism Is Associated With Lamotrigine Concentration-to-Dose Ratio in a Multivariate Study},
  author={Mar{\'i}a Blanca S{\'a}nchez and J. Herranz and C. Leno and R. Arteaga and A. Oterino and E. Valdiz{\'a}n and J. Nicol{\'a}s and J. Ad{\'i}n and M. Shushtarian and J. Armijo},
  journal={Therapeutic Drug Monitoring},
  year={2010},
  volume={32},
  pages={177-184}
}
Lamotrigine (LTG) is metabolized by UGT1A4 but UGT2B7 also contributes to its glucuronidation. The aim of this study was to determine whether UGT2B7_− 161C>T and UGT2B7_372A>G polymorphisms contribute to the intersubject variability in LTG concentration-to-dose ratio (LTG-CDR) in epileptic patients. Fifty-three white epileptic patients attending the Neuropediatric and Neurology Services at the Marqués de Valdecilla University Hospital, in whom LTG serum concentration was to be measured for… Expand
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