UGT1AI*6 and UGT1A1*27 for individualized irinotecan chemotherapy.

  title={UGT1AI*6 and UGT1A1*27 for individualized irinotecan chemotherapy.},
  author={Yuichi Ando and Ken-Ichi Fujita and Yasutsuna Sasaki and Yoshinori Hasegawa},
  journal={Current opinion in molecular therapeutics},
  volume={9 3},
Genetic polymorphisms of uridine 5'-diphospho-glucuronosyl-transferase (UGT)1A1, a crucial drug-metabolizing enzyme of the anticancer drug irinotecan, are essential determinants of individual variation in susceptibility to irinotecan-related toxicity. The FDA has revised the package insert of irinotecan in order to warn of the association between toxicity and UGTIA1*28, a variant sequence in a promoter region of the UGTIA1 gene. Unlike UGT1A1*28, UGT1AI*6 and UGTIA1*27 polymorphisms are found… CONTINUE READING

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