UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver.

@article{Girard2005UGT1A1PA,
  title={UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver.},
  author={Hugo Girard and Jean Thibaudeau and Michael H. Court and L C Fortier and Lyne Villeneuve and Patrick Caron and Qin Hao and Lisa L. von Moltke and David J Greenblatt and Chantal Guillemette},
  journal={Hepatology},
  year={2005},
  volume={42 2},
  pages={448-57}
}
PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine), the most abundant heterocyclic amine in diet, is involved in the etiology of cancer. PhIP and its carcinogenic metabolite N-hydroxy-PhIP (N-OH-PhIP) are extensively conjugated by UDP-glucuronosyltransferase (UGTs) with wide variability. This study aimed to determine the genetic influence of UGTs on the hepatic detoxification of this carcinogen. The formation of N-OH-PhIP glucuronides was studied in 48 human liver samples by mass… CONTINUE READING

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