UGT Genotype May Contribute to Adverse Events Following Medication With Mycophenolate Mofetil in Pediatric Kidney Transplant Recipients

@article{Prausa2009UGTGM,
  title={UGT Genotype May Contribute to Adverse Events Following Medication With Mycophenolate Mofetil in Pediatric Kidney Transplant Recipients},
  author={Susie Prausa and Tsuyoshi Fukuda and Denise Maseck and Kristi L Curtsinger and C Liu and Kun Zhang and Todd G. Nick and Joseph R. Sherbotie and Eileen N. Ellis and Jens Goebel and Aatmm Vinks},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2009},
  volume={85}
}
Leukopenia and diarrhea are the predominant adverse events associated with mycophenolate mofetil (MMF), leading to dose reduction or discontinuation in children. Polymorphisms of the drug's main metabolizing enzyme, uridine diphosphate–glucuronosyl transferase (UGT), confer alteration in drug exposure. We studied the incidence of these polymorphisms in pediatric kidney transplant recipients experiencing MMF‐associated leukopenia and diarrhea. UGT genotypes of 16 affected children who recovered… 
Mycophenolic acid-related diarrhea is not associated with polymorphisms in SLCO1B nor with ABCB1 in renal transplant recipients
TLDR
Genotyping for ABCB1 or SLCO1B pretransplantation is unlikely to be of clinical value for individualization of MPA therapy.
UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients
TLDR
It is demonstrated that combined UGT1A9-440C>T, UGT2B7-900A>G, and MRP2-24T>C polymorphisms can be important predictors of interindividual variability in MPA exposure in the pediatric population.
Mycophenolate mofetil‐related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs
TLDR
Time to leukopenia did not differ between patients by induction agent, but 2 SNPs in IMPDH1 were associated with increased time to leucopenia and UGT2B7 may influence leuk Openia risk especially in patients without lymphocyte‐depleting induction.
Influence of Polymorphisms on Mycophenolate Mofetil - Induced Diarrhoea in Renal Transplanted Children
TLDR
IMPDH2  (IVS7+10T>C) and ABCC2 -24CC wild-type patients carrying IMPDH1 IVS7 + 10 T>C variant are biomarkers associated with diarrhoea in children treated with MMF.
Population Pharmacokinetics and Pharmacogenetics of Mycophenolic Acid Following Administration of Mycophenolate Mofetil in De Novo Pediatric Renal‐Transplant Patients
TLDR
Body weight, concomitant medication, and UGT2B7 genotype contribute significantly to the interindividual variability of MMF disposition in pediatric renal‐transplant patients.
The influence of UGT polymorphisms as biomarkers in solid organ transplantation.
Age-Related Variability of Mycophenolate Mofetil Exposure in Stable Pediatric Liver Transplant Recipients and Influences of Donor Characteristics
TLDR
A marked MPA underexposure was observed among young children receiving livers from pediatric donors, indicating that higher doses might be required to reach the same MPA exposure as in adolescents.
SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients.
TLDR
Results suggest for the first time that carriers of the SLCO1B1*5 allele seem to be protected from MPA-related ADRs.
Effect of UGT polymorphisms on pharmacokinetics and adverse reactions of mycophenolic acid in kidney transplant patients.
TLDR
The relevant literature is reviewed and significant influences of UGT polymorphisms, such as UGT1A8 (rs1042597, rs17863762) and UGT2B7 (rs7438135, rs7439366, rs7662029), on the pharmacokinetics of MPA and its metabolites and adverse reactions are summarized.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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