UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

  title={UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins},
  author={D. Hellerschmied and Max Roessler and Anita Lehner and L. Gazda and K. Stejskal and Richard Imre and K. Mechtler and Alexander Dammermann and T. Clausen},
  journal={Nature Communications},
Muscle development requires the coordinated activities of specific protein folding and degradation factors. UFD-2, a U-box ubiquitin ligase, has been reported to play a central role in this orchestra regulating the myosin chaperone UNC-45. Here, we apply an integrative in vitro and in vivo approach to delineate the substrate-targeting mechanism of UFD-2 and elucidate its distinct mechanistic features as an E3/E4 enzyme. Using Caenorhabditis elegans as model system, we demonstrate that UFD-2 is… Expand
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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
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The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation
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Biallelic UBE4A loss-of-function variants cause intellectual disability and global developmental delay.
  • U. S. Melo, D. Bonner, +25 authors H. Byers
  • Medicine
  • Genetics in medicine : official journal of the American College of Medical Genetics
  • 2021
Exome sequencing and international collaboration indicate that biallelic loss-of-function variants in UBE4A cause a novel intellectual disability syndrome, suggesting that Ube4A enzyme activity is required for normal development and neurological function. Expand


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