UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

@article{Hellerschmied2018UFD2IA,
  title={UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins},
  author={D. Hellerschmied and Max Roessler and Anita Lehner and L. Gazda and K. Stejskal and Richard Imre and K. Mechtler and Alexander Dammermann and T. Clausen},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
Muscle development requires the coordinated activities of specific protein folding and degradation factors. UFD-2, a U-box ubiquitin ligase, has been reported to play a central role in this orchestra regulating the myosin chaperone UNC-45. Here, we apply an integrative in vitro and in vivo approach to delineate the substrate-targeting mechanism of UFD-2 and elucidate its distinct mechanistic features as an E3/E4 enzyme. Using Caenorhabditis elegans as model system, we demonstrate that UFD-2 is… Expand
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