UDP-sugar accumulation drives hyaluronan synthesis in breast cancer.

Abstract

Increased uptake of glucose, a general hallmark of malignant tumors, leads to an accumulation of intermediate metabolites of glycolysis. We investigated whether the high supply of these intermediates promotes their flow into UDP-sugars, and consequently into hyaluronan, a tumor-promoting matrix molecule. We quantified UDP-N-Acetylglucosamine (UDP-GlcNAc… (More)
DOI: 10.1016/j.matbio.2017.12.015

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