UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation.

  title={UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation.},
  author={Takahito Nishiyama and Tomokazu Ohnuma and Yuu Inoue and Takehiko Kishi and Kenichiro Ogura and Akira Hiratsuka},
  journal={Biochemical and biophysical research communications},
  volume={371 2},
Menadione (2-methyl-1,4-naphthoquine), also known as vitamin K3, has been widely used as a model compound in the field of oxidative stress-related research. The metabolism of menadione has been studied, and it is known that menadione undergoes a two-electron reduction by NAD(P)H:Quinone oxidoreductase 1 (NQO1) after which the reduced form of menadione (2-methyl-1,4-naphthalenediol, menadiol) is glucuronidated and excreted in urine. To investigate which human UDP-glucuronosyltransferase (UGT… CONTINUE READING