UD-CG 115 — a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle

@article{Honerjger1984UDCG1,
  title={UD-CG 115 — a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle},
  author={P. Honerj{\"a}ger and Agnes Heiss and Monika Sch{\"a}fer-Korting and G. Sch{\"o}nsteiner and Melchior Reiter},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1984},
  volume={325},
  pages={259-269}
}
1. The mechanism of the positive inotropic effect of a benzimidazole-pyridazinone, UD-CG 115, was analysed in the isolated guinea-pig papillary muscle contracting isometrically at a frequency of 0.2 Hz. 2. UD-CG 115 produced a slowly developing and poorly reversible positive inotropic effect increasing with concentration (3–300 μmol/l). The effect amounted to 30 and 74% of the maximum inotropic effect of a standard, dihydroouabain, at 34 and 300 μmol/l, respectively. Low concentrations… CONTINUE READING
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