UCPs, at the interface between bioenergetics and metabolism.

@article{Bouillaud2016UCPsAT,
  title={UCPs, at the interface between bioenergetics and metabolism.},
  author={Fr{\'e}d{\'e}ric Bouillaud and Marie-Clotilde Alves-Guerra and Daniel Ricquier},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1863 10},
  pages={
          2443-56
        }
}
The first member of the uncoupling protein (UCP) family, brown adipose tissue uncoupling protein 1 (UCP1), was identified in 1976. Twenty years later, two closely related proteins, UCP2 and UCP3, were described in mammals. Homologs of these proteins exist in other organisms, including plants. Uncoupling refers to a deterioration of energy conservation between substrate oxidation and ADP phosphorylation. Complete energy conservation loss would be fatal but fine-tuning can be beneficial for… CONTINUE READING

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