UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity.

@article{Russell2003UCP3PR,
  title={UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity.},
  author={Aaron P Russell and Emmanuel Somm and Manu Praz and Antoinette Crettenand and Oliver Hartley and Astrid Melotti and J P Giacobino and Patrick Muzzin and Charles Gobelet and Olivier D{\'e}riaz},
  journal={The Journal of physiology},
  year={2003},
  volume={550 Pt 3},
  pages={855-61}
}
It has been proposed that mitochondrial uncoupling protein 3 (UCP3) behaves as an uncoupler of oxidative phosphorylation. In a cross-sectional study, UCP3 protein levels were found to be lower in all fibre types of endurance-trained cyclists as compared to healthy controls. This decrease was greatest in the type I oxidative fibres, and it was hypothesised that this may be due to the preferential recruitment of these fibres during endurance training. To test this hypothesis, we compared the… CONTINUE READING
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