UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.

@article{Vozza2014UCP2TC,
  title={UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.},
  author={Angelo Vozza and Giovanni Parisi and Francesco De Leonardis and Francesco Massimo Lasorsa and Alessandra Castegna and Daniela Amorese and Raffaele Marmo and Valeria M Calcagnile and Luigi Palmieri and Daniel Ricquier and Eleonora Paradies and Pasquale Scarcia and Ferdinando Palmieri and Fr{\'e}d{\'e}ric Bouillaud and Giuseppe Fiermonte},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 3},
  pages={960-5}
}
Uncoupling protein 2 (UCP2) is involved in various physiological and pathological processes such as insulin secretion, stem cell differentiation, cancer, and aging. However, its biochemical and physiological function is still under debate. Here we show that UCP2 is a metabolite transporter that regulates substrate oxidation in mitochondria. To shed light on its biochemical role, we first studied the effects of its silencing on the mitochondrial oxidation of glucose and glutamine. Compared with… CONTINUE READING
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