UCP1 deficiency increases susceptibility to diet-induced obesity with age.

@article{Kontani2005UCP1DI,
  title={UCP1 deficiency increases susceptibility to diet-induced obesity with age.},
  author={Yasuhide Kontani and Yufeng Wang and Kazuhiro Kimura and K-I Inokuma and Masataka Saito and T Suzuki-Miura and Zhao Wang and Yuya Sato and Nozomu Mori and Hitoshi Yamashita},
  journal={Aging cell},
  year={2005},
  volume={4 3},
  pages={147-55}
}
Loss of nonshivering thermogenesis in mice by inactivation of the mitochondrial uncoupling protein gene (Ucp1-/- mice) causes increased sensitivity to cold and unexpected resistance to diet-induced obesity at a young age. To clarify the role of UCP1 in body weight regulation throughout life and influence of UCP1 deficiency on longevity, we longitudinally analyzed the phenotypes of Ucp1-/- mice maintained in a room at 23 degrees C. There was no difference in body weight and lifespan between… CONTINUE READING

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