UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

@inproceedings{Goto2015UCHL1PD,
  title={UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α},
  author={Yoko Goto and Lihua Zeng and Chan Joo Yeom and Yuxi Zhu and Akiyo Morinibu and Kazumi Shinomiya and Minoru Kobayashi and Kiichi Hirota and Satoshi Itasaka and Michio Yoshimura and Keiji Tanimoto and Masae Torii and Terumasa Sowa and Toshi Menju and Makoto Sonobe and Hideaki Kakeya and Masakazu Toi and Hiroshi Date and Ester M Hammond and Masahiro Hiraoka and Hiroshi Harada},
  booktitle={Nature communications},
  year={2015}
}
Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the genes that activate HIF-1 and subsequently promote metastases have yet to be identified. Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel-Lindau-mediated ubiquitination of HIF-1α, the regulatory subunit of HIF-1, and consequently promotes metastasis. The aberrant overexpression of UCHL1 facilitates distant tumour metastases in a HIF-1-dependent manner in murine models of… CONTINUE READING
Highly Cited
This paper has 193 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 17 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

MAP 4 and MAP 6 expression in breast cancer cell lines

G. N. Eduardo, Díaz-Orea María Alicia, +6 authors Lara-Padilla Eleazar
2017
View 7 Excerpts
Highly Influenced

DUBs, New Members in the Hypoxia Signaling clUb

Front. Oncol. • 2016
View 3 Excerpts
Highly Influenced

The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression

International journal of molecular sciences • 2018
View 1 Excerpt

193 Citations

05010015020152016201720182019
Citations per Year
Semantic Scholar estimates that this publication has 193 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2013

clinical significance

Trifa, F. et al. Frequent CpG methylation of ubiquitin carbo sporadic, hereditary Tunisian breast cancer patients
Med. Oncol. 30, 418 • 2013

Similar Papers

Loading similar papers…