UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.

@article{Wen2018UCHL1IA,
  title={UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.},
  author={Yuetao Wen and Qingyuan Wu and Quanhong Shi and Yanfeng Xie and Wei Dan and Yangmei Chen and Limin Ma},
  journal={Biochemical and biophysical research communications},
  year={2018}
}
Mossy fiber sprouting (MFS) is a pathological phenomenon that is commonly observed in epilepsy, and plentiful data reveal that abnormal phosphorylated modification of Tau protein plays a critical role in MSF by the regulation of microtubule dynamics and axonal transport. Ubiquitin C-terminal hydrolase L1 (UCH-L1), a proteasomal deubiquitinating enzyme, has… CONTINUE READING