UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.

Abstract

Podocytes are terminally differentiated cells of the glomerular filtration barrier that react with hypertrophy in the course of injury such as in membranous nephropathy (MGN). The neuronal deubiquitinase ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed and activated in podocytes of human and rodent MGN. UCH-L1 regulates the mono-ubiquitin pool and… (More)
DOI: 10.1016/j.bbadis.2014.02.011

Topics

Cite this paper

@article{Lohmann2014UCHL1IP, title={UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.}, author={Frithjof Lohmann and Marlies Sachs and Tobias N. Meyer and Henning Sievert and Maja Tamara Lindenmeyer and Thorsten Wiech and Clemens David Cohen and Stefan Balabanov and R. A. K. Stahl and Catherine Meyer-Schwesinger}, journal={Biochimica et biophysica acta}, year={2014}, volume={1842 7}, pages={945-58} }