UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.

  title={UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.},
  author={Y. Teng and K. Rezvani and M. De Biasi},
  journal={Biochemical pharmacology},
  volume={97 4},
Neuronal nicotinic acetylcholine receptors (nAChRs) containing the α3 subunit are known for their prominent role in normal ganglionic transmission while their involvement in the mechanisms underlying nicotine addiction and smoking-related disease has been emerging only in recent years. The amount of information available on the maturation and trafficking of α3-containing nAChRs is limited. We previously showed that UBXN2A is a p97 adaptor protein that facilitates the maturation and trafficking… Expand
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