UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS.

@article{Wang2013UBXN1IW,
  title={UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS.},
  author={Penghua Wang and Long Yang and Gong Cheng and Guang Yang and Zhengyun Xu and Fuping You and Qingnan Sun and Rongtuan Lin and Erol Fikrig and Richard E Sutton},
  journal={Cell reports},
  year={2013},
  volume={3 4},
  pages={1057-70}
}
RNA viruses are sensed by RIG-I-like receptors (RLRs), which signal through a mitochondria-associated adaptor molecule, MAVS, resulting in systemic antiviral immune responses. Although RLR signaling is essential for limiting RNA virus replication, it must be stringently controlled to prevent damage from inflammation. We demonstrate here that among all tested UBX-domain-containing protein family members, UBXN1 exhibits the strongest inhibitory effect on RNA-virus-induced type I interferon… CONTINUE READING
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