UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.

@article{Zhang2014UBR5mediatedUO,
  title={UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.},
  author={Tianyi Zhang and Janet Cronshaw and Nnennaya Kanu and Ambrosius P Snijders and Axel Behrens},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 33},
  pages={12091-6}
}
The Mre11/Rad50/NBS1 (MRN) protein complex and ATMIN protein mediate ATM kinase signaling in response to ionizing radiation (IR) and chromatin changes, respectively. NBS1 and ATMIN directly compete for ATM binding, but the molecular mechanism favoring either NBS1 or ATMIN in response to specific stimuli is enigmatic. Here, we identify the E3 ubiquitin ligase UBR5 as a key component of ATM activation in response to IR. UBR5 interacts with ATMIN and catalyzes ubiquitination of ATMIN at lysine 238… CONTINUE READING
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