UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation.

@article{Sirisaengtaksin2014UBE4BPC,
  title={UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation.},
  author={Natalie Sirisaengtaksin and Monica B. Gireud and Qing Yu Yan and Yoshihisa Kubota and Denisse Meza and Jack C. Waymire and Peter E. Zage and Andrew J. Bean},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 5},
  pages={3026-39}
}
The signaling of plasma membrane proteins is tuned by internalization and sorting in the endocytic pathway prior to recycling or degradation in lysosomes. Ubiquitin modification allows recognition and association of cargo with endosomally associated protein complexes, enabling sorting of proteins to be degraded from those to be recycled. The mechanism that provides coordination between the cellular machineries that mediate ubiquitination and endosomal sorting is unknown. We report that the… CONTINUE READING
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