UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

@article{Wu2010UBE2SDE,
  title={UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.},
  author={Tao Wu and Yifat Merbl and Ying Huo and Jennifer L Gallop and Amit Tzur and Marc W Kirschner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 4},
  pages={
          1355-60
        }
}
The Anaphase-Promoting Complex (APC) is an E3 ubiquitin ligase that regulates mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal degradation. The mechanism of ubiquitin chain formation by APC and the resultant chain topology remains controversial. By using a single-lysine APC substrate to dissect the topology of ubiquitinated substrates, we find that APC-catalyzed ubiquitination has an intrinsic preference for the K11 linkage of ubiquitin that is… CONTINUE READING

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