UBE2O is a quality control factor for orphans of multiprotein complexes

@article{Yanagitani2017UBE2OIA,
  title={UBE2O is a quality control factor for orphans of multiprotein complexes},
  author={Kota Yanagitani and Szymon Juszkiewicz and R. Hegde},
  journal={Science},
  year={2017},
  volume={357},
  pages={472 - 475}
}
  • Kota Yanagitani, Szymon Juszkiewicz, R. Hegde
  • Published 2017
  • Biology, Medicine
  • Science
  • Removing orphan proteins from the system The degradation of excess subunits of protein complexes is a major quality-control problem for the cell. How such “orphans” are recognized and tagged for degradation is poorly understood. Two papers identify a protein quality-control pathway that acts on some of the most abundant protein complexes in the human body: hemoglobin and ribosomes (see the Perspective by Hampton and Dargemont). Yanagitani et al. show that the central player in this process is… CONTINUE READING
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