UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.

@article{Polge2016UBE2D2IN,
  title={UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.},
  author={C{\'e}cile Polge and Nathalie Koulmann and Agn{\`e}s Claustre and Marianne Jarzaguet and Bernard Serrurier and Lydie Combaret and Daniel M B{\'e}chet and Xavier A. Bigard and Didier Attaix and Daniel Taillandier},
  journal={The international journal of biochemistry & cell biology},
  year={2016},
  volume={79},
  pages={
          488-493
        }
}
The Ubiquitin Proteasome System (UPS) is mainly responsible for the increased protein breakdown observed in muscle wasting. The E3 ligase MuRF1 is so far the only enzyme known to direct the main contractile proteins for degradation (i.e. troponin I, myosin heavy chains and actin). However, MuRF1 does not possess any catalytic activity and thus depends on the presence of a dedicated E2 for catalyzing the covalent binding of polyubiquitin (polyUb) chains on the substrates. The E2 enzymes… CONTINUE READING
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