UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins.

@article{Zheng2008UBE1DC1AU,
  title={UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins.},
  author={Mei Qin Zheng and X. D. Gu and Dan Zheng and Zhenxing Yang and Fan Li and Jun Zhao and Youhua Xie and Chaoneng Ji and Y. C. Mao},
  journal={Journal of cellular biochemistry},
  year={2008},
  volume={104 6},
  pages={2324-34}
}
Ubiquitin and ubiquitin-like proteins are known to be covalently conjugated to a variety of cellular substrates via a three-step enzymatic pathway. These modifications lead to the degradation of substrates or change its functional status. The ubiquitin-activating enzyme (E1) plays a key role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. Ubiquitin-activating enzyme E1-domain containing 1 (UBE1DC1) had been proved to activate an ubiquitin-like… CONTINUE READING