U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies.

@article{Lapenta1997U937SCIDMX,
  title={U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies.},
  author={Caterina Lapenta and Stefano Fais and Paola Rizza and Massimo Spada and Mariantonia Logozzi and Stefania Parlato and Stefano Maria Santini and Maria Franca Pirillo and Filippo Belardelli and Enricos Proietti},
  journal={Antiviral research},
  year={1997},
  volume={36 2},
  pages={81-90}
}
In this study we attempted to develop a new xenochimeric model for HIV infection in SCID mice, characterized by an easy engraftment of target cells, high levels of viremia and long-lasting HIV-1 infection. SCID mice were injected subcutaneously with uninfected human U937 cells and cell-free HIV-1 (IIIB strain) or HIV-1-infected human peripheral blood lymphocytes (PBL). Mice were evaluated for tumor growth, viral infection at the tumor level (DNA-polymerase chain reaction (PCR), RNA-PCR) and… CONTINUE READING