U6 promoter-driven siRNA injection has nonspecific effects in zebrafish.

Abstract

RNA interference (RNAi) is a posttranscriptional gene silencing mechanism triggered by double-stranded RNA (dsRNA), which causes degradation of homologous mRNAs. RNAi has been observed in a wide range of eukaryotes, including fungi, plants and animals. In vertebrates, long dsRNA activates the interferon response and yields nonspecific degradation of mRNA… (More)
DOI: 10.1016/j.bbrc.2009.12.065

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Cite this paper

@article{Wang2010U6PS, title={U6 promoter-driven siRNA injection has nonspecific effects in zebrafish.}, author={Lu Wang and Jing-Yao Zhou and Ji-hua Yao and Daru Lu and Xiao-Jing Qiao and William WeiGuo Jia}, journal={Biochemical and biophysical research communications}, year={2010}, volume={391 3}, pages={1363-8} }