U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart.

@article{Wu2011U50488HIN,
  title={U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart.},
  author={Xiaodong Wu and Bo Zhang and Rong Fan and Lei Zhao and Yuemin Wang and Shumiao Zhang and Alan D. Kaye and Luyu Huang and Jianming Pei},
  journal={Cytokine},
  year={2011},
  volume={56 2},
  pages={503-7}
}
The role of the κ-opioid receptor in inflammation is not well understood. The aim of this study was to investigate whether the κ-opioid receptor agonist U50,488H modulates neutrophil accumulation and TNF-α induction in an ischemia-reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia-reperfusion (MI/R) alone, MI/R+U50,488H, MI/R+U50,488H+Wortmannin, and MI/R+U50,488H+L-NAME. The results demonstrated that compared to MI/R, U50,488H reduced… CONTINUE READING

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