U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation.

@article{Li1999U50488HinducedIO,
  title={U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation.},
  author={Jin Li and L Y Luo and Jason G. Krupnick and Jeffrey L. Benovic and Lee-Yuan Liu-Chen},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 17},
  pages={
          12087-94
        }
}
Agonist-promoted internalization of some G protein-coupled receptors has been shown to mediate receptor desensitization, resensitization, and down-regulation. In this study, we investigated whether opioids induced internalization of the human and rat kappa opioid receptors stably expressed in Chinese hamster ovary cells, the potential mechanisms involved in this process and its possible role in activation of mitogen-activated protein (MAP) kinase. Exposure of the human kappa receptor to the… CONTINUE READING
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